ras基因相关蛋白RAB7样蛋白1抗体
规格：1mg/1ml
英文名： RAB7L1
别名： DKFZp686P1051; Rab 7 like protein 1; RAB 7L; Rab7 like protein 1; RAB7 member RAS oncogene family like 1; RAB7L; Ras related protein Rab 7L1; Ras related protein Rab7L1.
分子量： 23kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RAB7L1
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
ras基因相关蛋白RAB7样蛋白1抗体产品介绍：Function: Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection. Subcellular Location: Cell membrane; Lipid-anchor; Cytoplasmic side. Post-translational modifications: In case of Salmonella enterica serovar Typhimurium (S.Typhimurium) infection, is proteolytically cleaved between Gly-41 and Val-42 by the GtgE viral protease encoded on the Gifsy-2 lysogen bacteriophage, which therefore prevents the recruitment of RAB29 to S.Typhimurium-containing vacuoles. In contrast, no proteolytically cleavage is detected in S.Typhi-infected cells (PubMed:22042847). DISEASE: ras基因相关蛋白RAB7样蛋白1抗体Colocalizes with LRRK2 along tubular structures emerging from Golgi apparatus (By similarity). Colocalizes with GM130 at the Golgi apparatus. Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus. Colocalizes with TGN46 at the trans-Golgi network (TGN). In Salmonella enterica serovar Typhi (S.Typhi) infected epithelial cells, is recruited and colocalized with both S.Typhi-containing vacuoles and dynamic tubules as well as those emerging from the vacuole toward the cell periphery. Similarity: Belongs to the small GTPase superfamily.ras基因相关蛋白RAB7样蛋白1抗体 Rab family. Gene ID: 8934 Database links: Entrez Gene: 8934 Human Entrez Gene: 226422 Mouse Entrez Gene: 171122 Rat Omim: 603949 Human SwissProt: O14966 Human SwissProt: Q91YQ1 Mouse SwissProt: Q63481 Rat Unigene: 115325 Human Unigene: 34027 Mouse Unigene: 4323 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
ras基因相关蛋白RAB7样蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid