鸟嘌呤核苷酸交换因子相关蛋白抗体
规格：1mg/1ml
英文名： SERGEF
别名： Deafness locus associated putative guanine nucleotide exchange factor; DELGEF; Gef; Gnef; GNEFR; Guanine nucleotide exchange factor related protein; MGC128942; MGC141208; MGC141209; Secretion regulati
分子量： 50kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SERGEF
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核 细胞浆 分泌型蛋白
产鸟嘌呤核苷酸交换因子相关蛋白抗体品介绍：Function: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity). Subcellular Location: Cytoplasmic and Nuclear Tissue Specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, 鸟嘌呤核苷酸交换因子相关蛋白抗体while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. DISEASE: A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)鸟嘌呤核苷酸交换因子相关蛋白抗体(q11.2;q22) with TCRA. Gene ID: 26297 Database links: Entrez Gene: 26297 Human Omim: 606051 Human SwissProt: Q9UGK8 Human Unigene: 32470 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
鸟嘌呤核苷酸交换因子相关蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid