激肽释放酶1抗体
规格：1mg/1ml
英文名： KLK1
别名： Kallikrein 1; Kallikrein-1; hK1; Klk6; KLKR; Glandular kallikrein 1; hK 1; Kallikrein serine protease 1; Kidney/pancreas/salivary gland kallikrein; Klk 6; Tissue kallikrein; Klk1b3; Klk1c1; Ngfg; rGK-
分子量： 26kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KLK1
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse, Rabbit,
细胞定位：
激肽释放酶1抗体产品介绍：background: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008] Function: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Tissue Specificity: Isoform 2 is expressed in pancreas,激肽释放酶1抗体 salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84. Post-translational modifications: The O-linked polysaccharides on Ser-93, Ser-104 and Ser-167 are probably the mucin type linked to GalNAc. In PubMed:3163150, GalNAc was detected with the corresponding peptides but not located. Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily. Contains 1 peptidase S1 domain. Gene ID: 3816 Database links: Entrez Gene: 3816 Human Entrez Gene: 24594 Rat GenBank: NP_002248.1 Human Omim: 147910 Human激肽释放酶1抗体 SwissProt: P06870 Human SwissProt: P00758 Rat Unigene: 123107 Human Unigene: 11331 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 激肽释放酶KLK是激肽系统的主要限速酶，它是一组存在于多数组织和体液中的丝氨酸蛋白酶，是一种肽链内切酶。KLK又称血管舒缓素，包括15个家族成员。在不同的组织中广泛表达,具有蛋白水解酶的活性。它特异性的在碳末端切割底物肽，可裂解激肽原释放具有活性的激肽，由激肽发挥对心血管系统及肾脏功能的调节作用。 组织KLK是一个大的基因家族，主要分布在肺、肾、血管、脑、肾上腺组织，为一种中等大小的糖蛋白。
产激肽释放酶1抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid