泛素样蛋白特异性蛋白酶6抗体
规格：1mg/1ml
英文名： SENP6
别名： 2810017C20Rik; FLJ11355; FLJ11887; KIAA0389; KIAA0797; SENP 6; Senp6; SENP6_HUMAN; Sentrin specific protease 6; Sentrin-specific protease 6; Sentrin/SUMO specific protease SENP6; Sentrin/SUMO-specific
分子量： 126kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SENP6
交叉反应：Human,
细胞定位：细胞核
泛素样蛋白特异性蛋白酶6抗体产品介绍：background: Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009] Function: Protease that deconjugates SUMO1, SUMO2 and SUMO3泛素样蛋白特异性蛋白酶6抗体 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombinaison. Subcellular Location: Nucleus. Tissue Specificity: Highly expressed in reproductive organs, such as testis, ovary and prostate. Similarity: Belongs to the peptidase C48 family. Gene ID: 26054 Database 泛素样蛋白特异性蛋白酶6抗体links: Entrez Gene: 26054 Human Entrez Gene: 421859 Chicken Entrez Gene: 462829 Chimpanzee Entrez Gene: 533853 Cow Entrez Gene: 481883 Dog Entrez Gene: 100068828 Horse Entrez Gene: 215351 Mouse Entrez Gene: 300860 Rat Entrez Gene: 716554 Rhesus monkey Omim: 605003 Human SwissProt: Q9GZR1 Human SwissProt: Q6P7W0 Mouse Unigene: 485784 Human Unigene: 28232 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
泛素样蛋白特异性蛋白酶6抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 表观遗传学 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid