硒蛋白SECIS结合蛋白2抗体
规格：1mg/1ml
英文名： SECISBP2
别名： DKFZp686C09169; OTTHUMP00000064929; OTTHUMP00000064930; OTTHUMP00000064931; OTTHUMP00000064932; RP11 89K14.1; SBP 2; SBP2; SEBP2_HUMAN; SECIS binding protein 2; SECIS-binding protein 2; SECISBP 2; SEC
分子量： 95kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SECISBP2
交叉反应：Human,
细胞定位：细胞核
硒蛋白SECIS结合蛋白2抗体产品介绍：background: The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] Function: Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by硒蛋白SECIS结合蛋白2抗体 SELB. Subcellular Location: Nucleus. Tissue Specificity: Expressed at high levels in testis. DISEASE: Defects in SECISBP2 are a cause of abnormal thyroid hormone metabolism (ATHYHM) [MIM:609698]. This phenotype is associated with a reduction in type II iodothyronine deiodinase activity. Gene ID: 79048 Database links: Entrez Gene: 79048 Human Entrez Gene: 464583 Chimpanzee Entrez Gene: 511202 硒蛋白SECIS结合蛋白2抗体Cow Entrez Gene: 476351 Dog Entrez Gene: 101128509 Gorilla Entrez Gene: 75420 Mouse Entrez Gene: 79049 Rat Entrez Gene: 697442 Rhesus monkey Omim: 607693 Human SwissProt: Q96T21 Human SwissProt: Q9QX72 Rat Unigene: 59804 Human Unigene: 25076 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
硒蛋白SECIS结合蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 信号转导 干细胞 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid