蛋白酪氨酸磷酸酶非受体型22抗体
规格：1mg/1ml
英文名： PTPN22
别名： Hematopoietic cell protein tyrosine phosphatase 70Z PEP; Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; Lymphoid specific protein tyrosine phosphatase; lymphoid-specifi
分子量： 92kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PTPN22
交叉反应：Human, Mouse, Rat, Dog,
细胞定位：细胞浆
蛋白酪氨酸磷酸酶非受体型22抗体产品介绍：background: This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009] Function: Seems to act on Cbl. May play a role in regulating the function of Cbl and its associated protein kinases. Acts as negative regulator of T cell receptor (TCR) signaling. Dephosphorylates and inactivates the SRC family kinases. Subcellular Location: Cytoplasm. Tissue Specificity: Predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells. Post-translational modifications: Phosphorylation on Ser-35 by 蛋白酪氨酸磷酸酶非受体型22抗体PKC/PRKCD abrogates its ability to dephosphorylate and inactivate the SRC family kinases. Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. Contains 1 tyrosine-protein phosphatase domain. Gene ID: 26191 Database links: Entrez Gene: 483124 Dog Entrez Gene: 100717611 Guinea pig Entrez Gene: 100059247 Horse Entrez Gene: 26191 Human Entrez Gene: 蛋白酪氨酸磷酸酶非受体型22抗体19260 Mouse Entrez Gene: 295338 Rat Omim: 600716 Human SwissProt: Q9Y2R2 Human SwissProt: P29352 Mouse Unigene: 535276 Human Unigene: 395 Mouse Unigene: 22891 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品应用：蛋白酪氨酸磷酸酶非受体型22抗体WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶 **细胞 t-**细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid