酪氨酸蛋白磷酸酶非受体型12抗体
规格：1mg/1ml
英文名： PTPN12
别名： Protein tyrosine phosphatase G1; Protein tyrosine phosphatase non receptor type 12; Protein-tyrosine phosphatase G1; PTN12_HUMAN; PTP PEST; PTP-PEST; PTPG1; Ptpn12; Tyrosine protein phosphatase non re
分子量： 88kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PTPN12
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆
酪氨酸蛋白磷酸酶非受体型12抗体产品介绍：background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008] Function: Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2. Subunit: Interacts with TGFB1I1 (By similarity). Interacts with 酪氨酸蛋白磷酸酶非受体型12抗体PSTPIP1. Interacts with PTK2B/PYK2. Interacts with LPXN (By similarity). {ECO:0000250}. Subcellular Location: Cytoplasm. Post-translational modifications: Phosphorylated by STK24/MST3 and this results in inhibition of its activity. {ECO:0000269|PubMed:17046825}. Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. Contains 1 tyrosine-protein phosphatase domain. Gene ID: 5782 Database links: Entrez Gene: 5782 Human Entrez Gene: 531877 Cow Entrez Gene: 19248 Mouse Entrez Gene: 117255 Rat酪氨酸蛋白磷酸酶非受体型12抗体 Omim: 600079 Human SwissProt: Q05209 Human SwissProt: P35831 Mouse SwissProt: Q63745 Rat Unigene: 34723 Cow Unigene: 61812 Human Unigene: 319117 Mouse Unigene: 10707 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
酪氨酸蛋白磷酸酶非受体型12抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 细胞周期蛋白 激酶和磷酸酶 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid