脯氨酸-丝氨酸-苏氨酸磷酸酶相互作用蛋白2抗体
规格：1mg/1ml
英文名： PSTPIP2
别名： Macrophage actin associated tyrosine phosphorylated protein; Macrophage actin-associated tyrosine-phosphorylated protein; MAYP; PPIP2_HUMAN; Proline serine threonine phosphatase interacting protein 2;
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PSTPIP2
交叉反应：Human, Mouse, Rat, Pig, Horse, Rabbit,
细胞定位：细胞膜
脯氨酸-丝氨酸-苏氨酸磷酸酶相互作用蛋白2抗体产品介绍：Function: Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity). Subunit: Homodimer (PubMed:19584923). Homotrimer PubMed:17964261). Interacts (via coiled-coil domain) with CD2AP, PTPN12 and PTPN18. Interacts (via SH3 domain) with ABL1 and WAS. Interacts (via SH3 and coiled-coil domains) with MEFV (via B-box zinc finger); the interaction allows binding of MEFV to PYCARD and facilitates formation of PYCARD pyroptosomes. Interacts with CD2, DNM2 and FASLG. Subcellular Location: Cell Membrane; peripheral membrane protein and Cytoplasmic (by similarity). Tissue Specificity: Highly expressed in the peripheral blood leukocytes, granulocytes and monocytes, namely in T-cells and natural killer cells, and in spleen. Weakly expressed in the thymus, small intestine, lung and placenta. Post-translational modifications: Dephosphorylated on Tyr-345 by PTPN18, this event negatively regulates the association of PSTPIP1 with SH2 domain-containing proteins as tyrosine kinase. Phosphorylation of Tyr-345 is probably required for subsequent phosphorylation at other tyrosine residues. Phosphorylation is induced by activation of the EGFR and PDGFR in a ABL1 dependent manner. The 脯氨酸-丝氨酸-苏氨酸磷酸酶相互作用蛋白2抗体phosphorylation regulates the interaction with WAS and with MEFV (By similarity). DISEASE: PAPA syndrome (PAPAS) [MIM:604416]: Characterized by autosomal dominant inheritance of early-onset, primarily affecting skin and joint tissues. Recurring inflammatory episodes lead to accumulation of sterile, pyogenic, neutrophil-rich material within the affected joints, ultimately resulting in significant脯氨酸-丝氨酸-苏氨酸磷酸酶相互作用蛋白2抗体 destruction. Similarity: Contains 1 F-BAR domain. Contains 1 SH3 domain. Gene ID: 9050 Database links: Entrez Gene: 9050 Human Entrez Gene: 19201 Mouse Entrez Gene: 307248 Rat SwissProt: Q9H939 Human SwissProt: Q99M15 Mouse Unigene: 567384 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
脯氨酸-丝氨酸-苏氨酸磷酸酶相互作用蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 结合蛋白 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid