蛋白酶激活复合物亚基1抗体
规格：1mg/1ml
英文名： PSME1
别名： 11S regulator complex alpha subunit; 11S regulator complex subunit alpha; 29 kD MCP activator subunit; 29kD MCP activator subunit; Activator of multicatalytic protease subunit 1; IFI5111; IGUP I-5111;
分子量： 29kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PSME1
交叉反应：Human, Mouse, Rat, Pig, Cow, Cynomolgus Monkey
细胞定位：细胞浆
蛋白酶激活复合物亚基1抗体产品介绍：background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator蛋白酶激活复合物亚基1抗体 have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Function: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. Subunit: Heterodimer蛋白酶激活复合物亚基1抗体 of PSME1 and PSME2, which forms a hexameric ring. PSME1 can form homoheptamers. Similarity: Belongs to the PA28 family. Gene ID: 5720 Database links: Entrez Gene: 5720 Human Entrez Gene: 510041 Cow Entrez Gene: 19186 Mouse Entrez Gene: 397572 Pig Entrez Gene: 29630 Rat Omim: 600654 Human SwissProt: Q4U5R3 Cow SwissProt: Q06323 Human SwissProt: P97371 Mouse SwissProt: Q64L94 Pig SwissProt: Q63797 Rat Unigene: 75348 Human Unigene: 830 Mouse Unigene: 2742 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
蛋白酶激活复合物亚基1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid