睾丸核蛋白NUT抗体
规格：1mg/1ml
英文名： NUT
别名： C15orf55; Chromosome 15 open reading frame 55; DKFZp434O192; MGC138683; MGC138684; Nuclear protein in testis; NUT; NUT_HUMAN; Protein NUT.
分子量： 120kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NUT
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核
睾丸核蛋白NUT抗体产品介绍：background: nuclear protein in testis is a 1,132 amino acid protein that is specifically expressed in testis. Belonging to the FAM22 family, NUT shuttles between nucleus and cytoplasm via a leptomycin-sensitive pathway. It is suggested that the translocation of the NUT gene is the cause of nuclear protein in testis midline carcinomas (NMC). NMCs are highly aggressive carcinomas typically arising in midline structures in young individuals. These carcinomas are characterized by the presence of a chromosomal rearrangement of the NUT gene on chromosome 15 (15q14), which results in a chromosomal translocation most commonly involving the BRD4 gene on chromosome 19p13. Endogenous BRD-NUT fusion proteins contribute to carcinogenesis by associating with chromatin and interfering with epithelial differentiation. Subcellular睾丸核蛋白NUT抗体 Location: Cytoplasm. Nucleus. Shuttles between nucleus and cytoplasm. Tissue Specificity: Specifically expressed in testis. Post-translational modifications: Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export. DISEASE: Note=A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) 睾丸核蛋白NUT抗体with BRD4 which produces a BRD4-NUT fusion protein. Note=A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with BRD3 which produces a BRD3-NUT fusion protein. Similarity: Belongs to the FAM22 family. Gene ID: 256646 Database links: Entrez Gene: 256646 Human Omim: 608963 Human SwissProt: Q86Y26 Human Unigene: 525769 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
睾丸核蛋白NUT抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 染色质和核信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid