单链DNA结合蛋白2抗体
规格：1mg/1ml
英文名： OBFC2A
别名： FLJ13624; FLJ22833; hSSB2; MGC111163; Nabp1; Nucleic acid-binding protein 1; OBFC2A; Oligonucleotide/oligosaccharide binding fold containing 2A; Oligonucleotide/oligosaccharide binding fold containing
分子量： 22kD
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human OBFC2A
交叉反应：Human, Mouse, Rat, Pig, Cow,
细胞定位：细胞核
单链DNA结合蛋白2抗体产品介绍：background: Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008] Function: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Subunit: Component of the单链DNA结合蛋白2抗体 SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1. {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. Subcellular Location: Nucleus. Localizes to nuclear foci following DNA damage. Similarity: Belongs to the SOSS-B family. 单链DNA结合蛋白2抗体SOSS-B2 subfamily. Contains 1 OB DNA-binding domain. Gene ID: 64859 Database links: Entrez Gene: 64859 Human Entrez Gene: 109019 Mouse Entrez Gene: 363227 Rat Omim: 612103 Human SwissProt: Q96AH0 Human SwissProt: Q8BGW5 Mouse SwissProt: Q5FVP2 Rat Unigene: 591610 Human Unigene: 196290 Mouse Unigene: 21433 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
单链DNA结合蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：结合蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid