核孔复合蛋白Nup214抗体
规格：1mg/1ml
英文名： NUP214
别名： 214 kDa nucleoporin; CAIN; CAN; CAN protein putative oncogene; D9S46E; N214; NU214_HUMAN; Nuclear pore complex protein Nup214; nucleoporin 214kDa; Nucleoporin Nup214; Nup214; p250; Protein CAN.
分子量： 213kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NUP214
交叉反应：Human, Mouse, Chimpanzee,
细胞定位：细胞核
核孔复合蛋白Nup214抗体产品介绍：background: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated 核孔复合蛋白Nup214抗体with acute myeloid leukemia and myelodysplastic syndrome. [provided by RefSeq, Jul 2008] Function: May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. Subcellular Location: Nucleus > nuclear pore complex. Cytoplasmic filaments. Tissue Specificity: Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development. Post-translational modifications: Probably glycosylated as it reacts with wheat germ agglutinin 核孔复合蛋白Nup214抗体(WGA). DISEASE: Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET. Gene ID: 8021 Database links: Entrez Gene: 8021 Human Omim: 114350 Human SwissProt: P35658 Human Unigene: 654530 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
核孔复合蛋白Nup214抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：染色质和核信号 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid