NUDT3蛋白抗体
规格：1mg/1ml
英文名： NUDT3
别名： Diphosphoinositol polyphosphate phosphohydrolase 1; Diphosphoinositol polyphosphate phosphohydrolase; DIPP 1; DIPP; DIPP-1; DIPP1; Nucleoside diphosphate linked moiety X motif 3; Nucleoside diphosphat
分子量： 19kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NUDT3
交叉反应：Human, Mouse, Rat, Cow,
细胞定位：细胞浆
NUDT3蛋白抗体产品介绍：background: NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011] Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoriboseNUDT3蛋白抗体 1-diphosphate. Subcellular Location: Cytoplasm. Tissue Specificity: Widely expressed. Expressed at higher level in brain, heart, pancreas and liver. Also expressed in placenta, lung and kidney. Similarity: Belongs to the Nudix hydrolase family. DIPP subfamily. Contains 1 nudix hydrolase domain. Gene ID: 11165 Database links: Entrez Gene: 11165 Human Entrez Gene: 618855 Cow Entrez Gene: 56409 Mouse Entrez Gene: NUDT3蛋白抗体294292 Rat Omim: 609228 Human SwissProt: A2VE79 Cow SwissProt: O95989 Human SwissProt: Q9JI46 Mouse SwissProt: Q566C7 Rat Unigene: 188882 Human Unigene: 728786 Human Unigene: 144699 Mouse Unigene: 32556 Mouse Unigene: 473041 Mouse Unigene: 195252 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
NUDT3蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid