核酸内切酶III样蛋白1抗体
规格：1mg/1ml
英文名： NTH1
别名： Bifunctional DNA N glycoslyase/DNA (apurinic or apyrimidinic site) lyase; DNA glycoslyase/AP lyase; Endonuclease III like protein 1; Endonuclease III-like protein 1; hNTH1; NTH 1; nth endonuclease III
分子量： 31kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NTH1
交叉反应：Human,
细胞定位：细胞核
核酸内切酶III样蛋白1抗体产品介绍：background: The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. [provided by RefSeq, Oct 2008] Function: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite核酸内切酶III样蛋白1抗体 guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption. Subcellular Location: Nucleus. Tissue Specificity: Widely expressed with highest levels in heart and lowest levels in lung and liver.核酸内切酶III样蛋白1抗体 Similarity: Belongs to the Nth/MutY family. Gene ID: 4913 Database links: Entrez Gene: 4913 Human Entrez Gene: 18207 Mouse Entrez Gene: 29541 Rat Omim: 602656 Human SwissProt: P78549 Human SwissProt: O35980 Mouse Unigene: 66196 Human Unigene: 148315 Mouse Unigene: 14632 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
核酸内切酶III样蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid