转运RNA（胞嘧啶5）甲基转移酶NSUN2抗体
规格：1mg/1ml
英文名： NSUN2
别名： 5 methycytoisine methyltransferase; D13Wsu123e; FLJ20303; hTrm4; MISU; Myc induced SUN domain containing protein; NOL1/NOP2/Sun domain family 2; NOL1/NOP2/Sun domain family 2 protein; NOL1/NOP2/Sun do
分子量： 86kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NSUN2
交叉反应：Human,
细胞定位：细胞核 细胞浆
转运RNA（胞嘧啶5）甲基转移酶NSUN2抗体产品介绍：background: This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2011] Function: RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Not able to modify tRNAs at positions 48 or 49. May act downstream of Myc to regulate epidermal cell growth and proliferation. Subcellular Location: Nucleus > nucleolus. Cytoplasm. Concentrated in the nucleolus during interphase and distributed in the perichromosome and cytoplasm during mitosis.转运RNA（胞嘧啶5）甲基转移酶NSUN2抗体 Post-translational modifications: Phosphorylated at Ser-139 by Aurora-B/STK12 during mitosis, leading to abolish methyltransferase activity and the interaction with NPM1. DISEASE: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Similarity: Belongs to the 转运RNA（胞嘧啶5）甲基转移酶NSUN2抗体methyltransferase superfamily. RsmB/NOP family. TRM4 subfamily. Gene ID: 54888 Database links: Entrez Gene: 54888 Human Entrez Gene: 28114 Mouse Entrez Gene: 361191 Rat Omim: 610916 Human SwissProt: Q08J23 Human SwissProt: Q1HFZ0 Mouse Unigene: 481526 Human Unigene: 260009 Mouse Unigene: 27691 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
转运RNA（胞嘧啶5）甲基转移酶NSUN2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：发育生物学 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid