26S蛋白酶体非ATP酶调节亚基11抗体
规格：1mg/1ml
英文名： PSMD11
别名： 26S proteasome non-ATPase regulatory subunit 11; 26S proteasome regulatory subunit 9; 26S proteasome regulatory subunit p44.5; 26S proteasome regulatory subunit RPN6; 26S proteasome regulatory subunit
分子量： 38kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PSMD11
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Zebrafish, Guinea Pig, Cat,
细胞定位：细胞核 细胞浆
26S蛋白酶体非ATP酶调节亚基11抗体产品介绍：background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012] Function: Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.26S蛋白酶体非ATP酶调节亚基11抗体 In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. Subcellular Location: Nucleus. Cytoplasm > cytosol. Tissue Specificity: Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate. Post-translational modifications: Phosphorylated by AMPK. Similarity: Belongs to the proteasome subunit S9 family. Contains 1 PCI domain. Database links: Entrez Gene: 513461 Cow Entrez Gene: 480610 Dog Entrez Gene: 5717 Human Entrez Gene: 69077 Mouse Entrez 26S蛋白酶体非ATP酶调节亚基11抗体Gene: 303353 Rat Entrez Gene: 322265 Zebrafish Omim: 604449 Human SwissProt: Q2KI42 Cow SwissProt: O00231 Human SwissProt: Q8BG32 Mouse SwissProt: F1LMZ8 Rat Unigene: 443379 Human Unigene: 260539 Mouse Unigene: 11861 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
26S蛋白酶体非ATP酶调节亚基11抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid