蛋白酶体26S亚基ATP酶3相互作用蛋白抗体
规格：1mg/1ml
英文名： PSMC3IP
别名： 26S protease regulatory subunit 6A; 26S proteasome AAA-ATPase subunit RPT5; Human immunodeficiency virus tat transactivator binding protein 1; MGC8487; Proteasome (prosome macropain) 26S subunit ATPas
分子量： 24kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PSMC3IP
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Cat,
细胞定位：细胞核
蛋白酶体26S亚基ATP酶3相互作用蛋白抗体产品介绍：background: This gene encodes a protein that functions in meiotic recombination. It is a subunit of the PSMC3IP/MND1 complex, which interacts with PSMC3/TBP1 to stimulate DMC1- and RAD51-mediated strand exchange during meiosis. The protein encoded by this gene can also co-activate ligand-driven transcription mediated by estrogen, androgen, glucocorticoid, progesterone, and thyroid nuclear receptors. Mutations in this gene cause XX female gonadal dysgenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2011] Function: Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as蛋白酶体26S亚基ATP酶3相互作用蛋白抗体 a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors. Subcellular Location: Nucleus. Tissue Specificity: Highly expressed in testis and colon. Post-translational modifications: PTM: Phosphorylated by PKA, PKC and MAPK. DISEASE: Ovarian dysgenesis 3 (ODG3) [MIM:614324]: A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. Note=The disease is caused by mutations affecting the 蛋白酶体26S亚基ATP酶3相互作用蛋白抗体gene represented in this entry. Similarity: Belongs to the HOP2 family. Database links: ntrez Gene: 29893 Human Entrez Gene: 19183 Mouse Entrez Gene: 140938 Rat Omim: 608665 Human SwissProt: Q9P2W1 Human SwissProt: O35047 Mouse SwissProt: Q91ZY6 Rat Unigene: 383019 Human Unigene: 18344 Mouse Unigene: 144650 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
蛋白酶体26S亚基ATP酶3相互作用蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid