丝氨酸/苏氨酸激酶家族成员的基因WNK3抗体
规格：1mg/1ml
英文名： WNK3
别名： Serine/threonine-protein kinase WNK3; WNK lysine deficient protein kinase 3; Protein kinase with no lysine 3; Protein kinase, lysine-deficient 3; Wnk3; RGD1563131; KIAA1566; PRKWNK 3; PRKWNK-3; PRKWNK
分子量： 198kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human WNK3 pro
交叉反应：Human, Mouse, Rat, Cow, Rabbit,
细胞定位：细胞浆
丝氨酸/苏氨酸激酶家族成员的基因WNK3抗体产品介绍：background: WNK3 (WNK lysine deficient protein kinase 3) belongs to the serine/threonine protein kinase family. It lacks the almost invariant catalytic lysine in subdomain II, which is important for binding ATP in the catalytic site. A conserved lysine in subdomain I is thought to provide this function. WNK3 activates Na-(K)-Cl cotransporters by increasing their phosphorylation and appears to be a crucial component of the kinase/phosphatase signaling pathway that coordinately regulates the Cl– influx and efflux branches of the SLC12A cotransporter family. Subunit: Interacts with WNK1 and WNK4. Subcellular Location: Cytoplasm. Tissue Specificity丝氨酸/苏氨酸激酶家族成员的基因WNK3抗体: Expressed in brain, lung, kidney, liver and pancreas, and in fetal tissues including placenta, fetal brain, lung and kidney. Very low levels of expression were also detected in fetal heart, thymus, liver and spleen. Isoform 1 is brain-specific丝氨酸/苏氨酸激酶家族成员的基因WNK3抗体. Isoform 3 is kidney-specific. Similarity: BBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily. Contains 1 protein kinase domain. Gene ID: 65267 Database links: Entrez Gene: 65267 Human Omim: 300358 Human SwissProt: Q9BYP7 Human Unigene: 92423 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
丝氨酸/苏氨酸激酶家族成员的基因WNK3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 染色质和核信号 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid