PC4和SFRS1相互作用蛋白抗体
规格：1mg/1ml
英文名： PSIP1
别名： CLL associated antigen KW 7; CLL-associated antigen KW-7; Dense fine speckles 70 kDa protein; DFS 70; DFS70; LEDGF; Lens epithelium derived growth factor; Lens epithelium-derived growth factor; MGC747
分子量： 60kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PSIP1
交叉反应：Human, Mouse, Rat, Chicken, Cow,
细胞定位：细胞核
PC4和SFRS1相互作用蛋白抗体产品介绍：background: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. Subcellular Location: Nucleus. Remains chromatin-associated throughout the cell cycle. Tissue Specificity: Widely expressed. Expressed at high level in the thymus. Expressed in fetal and ***** brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to ***** brain. In PC4和SFRS1相互作用蛋白抗体the ***** brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. DISEASE: Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4. Similarity: Belongs to the HDGF family. Contains 1 PWWP domain. Gene ID: 11168 PC4和SFRS1相互作用蛋白抗体Database links: Entrez Gene: 11168 Human Entrez Gene: 282011 Cow Entrez Gene: 101739 Mouse Entrez Gene: 313323 Rat Omim: 603620 Human SwissProt: Q66T72 Cat SwissProt: O75475 Human SwissProt: Q99JF8 Mouse SwissProt: Q812D1 Rat Unigene: 726445 Human Unigene: 105331 Mouse Unigene: 448301 Mouse Unigene: 93075 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PC4和SFRS1相互作用蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid