蛋白酶体抑制剂亚基PI31抗体
规格：1mg/1ml
英文名： PSMF1
别名： hPI31; PI31; Proteasome Inhibitor subunit 1 PI3 1; Proteasome (prosome macropain) inhibitor subunit 1; Proteasome inhibitor hP131 subunit; Proteasome inhibitor PI31 subunit; PSMB2; PSMF1; PSMF1_HUMAN;
分子量： 30kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PSMF1
交叉反应：Human,
细胞定位：
蛋白酶体抑制剂亚基PI31抗体产品介绍：background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. [provided by蛋白酶体抑制剂亚基PI31抗体 RefSeq, Jul 2008] Function: Plays an important role in control of proteasome function. Inhibits the 蛋白酶体抑制剂亚基PI31抗体hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28. Similarity: Belongs to the proteasome inhibitor PI31 family. Gene ID: 9491 Database links: Entrez Gene: 9491 Human Entrez Gene: 228769 Mouse Entrez Gene: 689852 Rat SwissProt: Q92530 Human SwissProt: Q8BHL8 Mouse SwissProt: Q5XIU5 Rat Unigene: 471917 Human Unigene: 146984 Mouse Unigene: 103325 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
蛋白酶体抑制剂亚基PI31抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid