SAPS结构域家族3抗体
规格：1mg/1ml
英文名： SAPS3
别名： C11orf23; Chromosome 11 open reading frame 23; KIAA1558; PP6R3; PP6R3_HUMAN; PPP6R3; Protein phosphatase 6 regulatory subunit 3; SAP190; SAPL; SAPLa; SAPS domain family member 3; SAPS domain family, m
分子量： 98kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SAPS3
交叉反应：Human, Mouse, Chicken, Horse, Chimpanzee, Rhesus monkey, Gorilla, Chinese Hamster, Orangutan
细胞定位：细胞核 细胞浆
SAPS结构域家族3抗体产品介绍：background: Protein phosphatase regulatory subunits, such as SAPS3, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS3 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010] Function: Regulatory subunit of protein phospatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. Subunit: Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containingSAPS结构域家族3抗体 regulatory subunit (ARS). Interacts with PPP6C and ANKRD28. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Expressed in skeletal muscle, placenta, heart, pancreas, testis, brain, lung, liver, kidney, spleen, thymus, prostate, small intestine, SAPS结构域家族3抗体colon and leukocytes. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the SAPS family. Database links: Entrez Gene: 55291 Human Entrez Gene: 52036 Mouse Omim: 610879 Human SwissProt: Q5H9R7 Human SwissProt: Q922D4 Mouse Unigene: 503022 Human Unigene: 284686 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
SAPS结构域家族3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid