SAPS结构域家族1抗体
规格：1mg/1ml
英文名： SAPS1
别名： PP6R1; Protein phosphatase 6, regulatory subunit 1; SAP190; SAPS domain family, member 1.
分子量： 117kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SAPS1
交叉反应：Human, Mouse, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
细胞定位：细胞浆
SAPS结构域家族1抗体产品介绍：background: Protein phosphatase regulatory subunits, such as SAPS1, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS1 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010] Function: Regulatory subunit of protein phosphatase 6 (PP6).SAPS结构域家族1抗体 May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Subunit: Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed of the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6C and NFKBIE. Interacts with ANKRD28, ANKRD44 and SAPS结构域家族1抗体ANKRD52. Subcellular Location: Cytoplasm Tissue Specificity: Ubiquitous with higher expression in testis. Similarity: Belongs to the SAPS family. Database links: Entrez Gene: 22870 Human Omim: 610875 Human SwissProt: Q9UPN7 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
SAPS结构域家族1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid