磷酸化泛素样蛋白SUMO1激活酶抗体
规格：1mg/1ml
英文名： phospho-SAE1 (Ser185)
别名： SAE1 (phospho S185); p-SAE1 (phospho S185); Activator of SUMO1; AOS 1; AOS1; FLJ3091; HSPC 140; HSPC140; SAE 1; Sae1; SAE1_HUMAN; Sentrin/SUMO activating protein AOS 1; Sentrin/SUMO activating protein
分子量： 38kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Chimpanzee,
细胞定位：细胞核
磷酸化泛素样蛋白SUMO1激活酶抗体产品介绍：background: Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010] Function: The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Subcellular Location: Nucleus. Tissue Specificity: Expression level increases during S phase and drops in磷酸化泛素样蛋白SUMO1激活酶抗体 G2 phase (at protein level). Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the ubiquitin-activating E1 family. Database links: Entrez Gene: 505512 Cow Entrez Gene: 476425 Dog Entrez Gene: 10055 Human Entrez Gene: 56459 Mouse Entrez Gene: 308384 Rat Omim: 613294 Human SwissProt: A2VE14 Cow SwissProt: Q9UBE0 Human 磷酸化泛素样蛋白SUMO1激活酶抗体SwissProt: Q9R1T2 Mouse SwissProt: Q6AXQ0 Rat Unigene: 515500 Human Unigene: 258530 Mouse Unigene: 9014 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化泛素样蛋白SUMO1激活酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid