线粒体脱偶连蛋白3抗体
规格：1mg/1ml
英文名： UCP-3
别名： Uncoupling Protein-3; UCP3; UCP 3; mitochondrial uncoupling protein 3; Solute carrier family 25 member 9; SLC25A9; UCP3_HUMAN.
分子量： 34kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human UCP-3
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆 细胞膜
线粒体脱偶连蛋白3抗体产品介绍：background: The uncoupling proteins (UCPs) are found in the inner mitochondrial membranes and belong to a family of mitochondrial anion transport proteins that include the phosphate and oxologutarate carriers and the ADP/ATP translocator. Three UCP subtypes have been identified and cloned. UCP 1 is abundantly expressed in brown adipose tissue of mammals. UCP 1 allows proton re-entry into the mitochondrial matrix without involving the F0-F1 ATPase which produces heat instead of ATP. It is thought that UCP 2 and 3 also dissipate the mitochondrial proton gradient produced by the respiratory chain in cells and tissues within which they are expressed. Studies have shown UCP 2 to be expressed by a variety of tissues. UCP 3 is expressed predominantly in brown adipose tissue, skeletal muscle, at lower levels in heart and smooth muscle, and is absent in liver and kidney. Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the线粒体脱偶连蛋白3抗体modulation of tissue respiratory control. Participates in thermogenesis and energy balance. Subcellular Location: mitochondrial.Mitochondrion inner membrane; Multi-pass membrane protein. Tissue Specificity: Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles. DISEASE: Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Note=The gene represented in this entry may线粒体脱偶连蛋白3抗体 be involved in disease pathogenesis. Similarity: Belongs to the mitochondrial carrier family. Gene ID: 7352 Database links: Entrez Gene: 7352 Human Entrez Gene: 22229 Mouse Entrez Gene: 397116 Pig Entrez Gene: 25708 Rat Omim: 602044 Human SwissProt: P55916 Human SwissProt: P56501 Mouse SwissProt: O97649 Pig SwissProt: P56499 Rat Unigene: 101337 Human Unigene: 621879 Human Unigene: 6254 Mouse Unigene: 9902 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
线粒体脱偶连蛋白3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid