神经调节蛋白4抗体
规格：1mg/1ml
英文名： NRG4
别名： DKFZp779N0541; DKFZp779N1944; Heregulin 4; HRG4; Neuregulin 4; Neuregulin-4; NRG-4; NRG4; NRG4_HUMAN; pro-neuregulin-4, membrane-bound isoform; Pro-NRG4.
分子量： 13kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NRG4
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜 分泌型蛋白
神经调节蛋白4抗体产品介绍：background: The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008] Function: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. Subcellular Location: Secreted and Cell membrane. Does not seem to be active. Post-translational modifications: Proteolytic cleavage close to 神经调节蛋白4抗体the plasma membrane on the external face leads to the release of the soluble growth factor form. Extensive glycosylation precedes the proteolytic cleavage. Similarity: Belongs to the neuregulin family. Contains 1 EGF-like domain. Database links: Entrez 神经调节蛋白4抗体Gene: 145957 Human Entrez Gene: 83961 Mouse Entrez Gene: 690919 Rat Omim: 610894 Human SwissProt: Q8WWG1 Human SwissProt: Q9WTX4 Mouse Unigene: 732438 Human Unigene: 443874 Mouse Unigene: 120491 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
神经调节蛋白4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid