自然抗性相关巨噬细胞蛋白1抗体
规格：1mg/1ml
英文名： NRAMP1
别名： LSH; Natural resistance associated macrophage protein 1; Natural resistance-associated macrophage protein 1; NRAM1_HUMAN; NRAMP 1; NRAMP; PBC; SLC11A1; Solute carrier family 11 (proton coupled divalen
分子量： 60kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NRAMP1
交叉反应：Human, Rat, Cow, Rabbit,
细胞定位：细胞膜
自然抗性相关巨噬细胞蛋白1抗体产品介绍：background: This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008] Function: Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites自然抗性相关巨噬细胞蛋白1抗体. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes. Subcellular Location: Membrane. Tissue Specificity: Macrophages; peripheral blood leukocytes, lung, spleen and liver. Similarity: Belongs to the NRAMP family. Gene ID: 6556 Database links: Entrez Gene: 6556 Human Entrez Gene: 18173自然抗性相关巨噬细胞蛋白1抗体 Mouse Entrez Gene: 316519 Rat Omim: 600266 Human SwissProt: P49279 Human SwissProt: P41251 Mouse SwissProt: P70553 Rat Unigene: 591607 Human Unigene: 2913 Mouse Unigene: 105919 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
自然抗性相关巨噬细胞蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid