核定位蛋白4抗体
规格：1mg/1ml
英文名： NPL4
别名： KIAA1499; NPL4; NPL4, S. cerevisiae, homolog of; NPL4_HUMAN; nploc4; nuclear protein localization 4 homolog (S. cerevisiae); Nuclear protein localization 4 homolog; Nuclear protein localization protei
分子量： 68kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NPL4
核定位蛋白4抗体交叉反应：Human, Mouse, Rat, Cow, Sheep,
细胞定位：细胞浆
产品介绍：background: The NPL4 gene encodes the 608-amino acid, endoplasmic reticulum and nuclear membrane protein Npl4 that forms a complex with p97/Cdc48p and Ufd1p. This complex plays a role in IP3 receptor processing by recognizing ubiquitinated IP3 receptors in the endoplasmic reticulum and delivering them to the proteasome for degradation. The Npl4 protein contains 8 potential N-myristoylation sites, 5 potential N-glycosylation sites, several phosphorylation sites, and a C-terminal zinc finger motif. This protein is 96% homologous to the rat Npl4 protein, 44% homologous to the Caenorhabditis elegans Npl4 protein, and 34% homologous to the Saccharomyces cerevisiae Npl4 protein. Mutations in the NPL4 gene cause defects in nuclear envelope morphology, nuclear protein import, and nuclear poly(A) RNA export. Function: The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the 核定位蛋白4抗体ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Subcellular Location: Cytoplasm; cytosol. Endoplasmic reticulum. Nucleus. Associated with the endoplasmic reticulum and nuclear. Tissue Specificity: Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver. Similarity: Belongs to the NPL4 family. Contains 1 RanBP2-type zinc finger. Gene ID: 55666 Database links: Entrez Gene: 核定位蛋白4抗体55666 Human Entrez Gene: 217365 Mouse Entrez Gene: 140639 Rat Omim: 606590 Human SwissProt: Q8TAT6 Human SwissProt: P60670 Mouse SwissProt: Q9ES54 Rat Unigene: 464333 Human Unigene: 309520 Mouse Unigene: 144645 Rat Unigene: 217306 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
核定位蛋白4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid