核蛋白共济失调****扩张症蛋白抗体
规格：1mg/1ml
英文名： NPAT
别名： E14; nuclear protein ataxia telangiectasia locus; nuclear protein in the AT region.
分子量： 154kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NPAT
交叉反应：Human, Mouse, Rat, Chimpanzee, Gorilla, Orangutan
核蛋白共济失调****扩张症蛋白抗体细胞定位：细胞核
产品介绍：background: NPAT is a 240kDa protein that associates with and can be phosphorylated by the CDK cyclin E–CDK2. The protein level of NPAT peaks at the G1/S boundary. Overexpression of NPAT accelerates S-phase entry suggesting that NPAT plays a role in S-phase entry. Function: Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT)核蛋白共济失调****扩张症蛋白抗体 complex to target gene promoters. Subcellular Location: Nuclear Post-translational modifications: Phosphorylated at Ser-775, Ser-779, Ser-1100, Thr-1270 and Thr-1350 by CCNE1/CDK2 at G1-S transition and until prophase, which promotes association with histone gene clusters and stimulates activation of histone transcription. Also phosphorylated by CCNA1/CDK2 in vitro. Gene ID: 4863 Database核蛋白共济失调****扩张症蛋白抗体 links: Entrez Gene: 4863 Human Omim: 601448 Human SwissProt: Q13632 Human SwissProt: Q14207 Human SwissProt: Q16580 Human Unigene: 171061 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产核蛋白共济失调****扩张症蛋白抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 神经生物学 细胞周期蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid