磷酸化一氧化氮合成酶-1（神经型）抗体
规格：1mg/1ml
英文名： phospho-nNOS (Ser1417)
别名： nNOS (neuronal) (phospho S1417); p-nNOS (neuronal) (phospho S1417); 2310005C01Rik; bNOS; Constitutive NOS; EC 1.14.13.39; IHPS 1; IHPS1; N NOS; N-NOS; NC NOS; NC-NOS; neuronal Nitric Oxide Synthase; N
分子量： 160kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Zebrafish, Xenopus laevis
细胞定位：细胞膜
磷酸化一氧化氮合成酶-1（神经型）抗体产品介绍：background: The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011] Function: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. 磷酸化一氧化氮合成酶-1（神经型）抗体In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Subcellular Location: Cell membrane; sarcolemma. Cell projection; dendritic spine. In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines. Tissue Specificity: Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. 磷酸化一氧化氮合成酶-1（神经型）抗体Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland. Post-translational modifications: Ubiquitinated; mediated by STUB1/CHIP in the presence of Hsp70 and Hsp40 (in vitro). Similarity: Belongs to the NOS family. Contains 1 FAD-binding FR-type domain. Contains 1 flavodoxin-like domain. Contains 1 PDZ (DHR) domain. Gene ID: 4842 Database links: Entrez Gene: 4842 Human Entrez Gene: 18125 Mouse Entrez Gene: 100009243 Rabbit Entrez Gene: 24598 Rat Entrez Gene: 60658 Zebrafish Omim: 163731 Human SwissProt: P29475 Human SwissProt: Q9Z0J4 Mouse SwissProt: O19132 Rabbit SwissProt: P29476 Rat Unigene: 654410 Human Unigene: 684465 Human Unigene: 684466 Human Unigene: 684467 Human Unigene: 442195 Mouse Unigene: 44249 Mouse Unigene: 10573 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化一氧化氮合成酶-1（神经型）抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid