NMRAL1蛋白抗体
规格：1mg/1ml
英文名： NMRAL1
别名： FLJ25918; HSCARG; NmrA like family domain containing 1; NmrA like family domain containing protein 1; NmrA-like family domain-containing protein 1; NMRAL1; NMRL1_HUMAN; SDR48A1.
分子量： 33kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NMRAL1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Guinea Pig,
细胞定位：细胞浆
NMRAL1蛋白抗体产品介绍：background: HSCARG is a 299 amino acid redox sensor protein that belongs to the NmrA-type oxidoreductase family. Localizing primarily to the cytoplasm and perinuclear region, HSCARG localization to the nucleus may occur with increased intracellular nitric oxide and reduced NADPH/NADP+ ratios. Existing as a homodimer, HSCARG interacts with ASS1, inhibiting ASS1 activity in the presence of low NADPH/NADP+ ratios. HSCARG gets induced by nitric oxide, cGMP and proinflammatory cytokines. The gene encoding HSCARG maps to human chromosome 16p13.3 and mouse chromosome 16 A1. Overexpression of the gene encoding HSCARG results in increased cell viability. Function: Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis.NMRAL1蛋白抗体 Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer. Subcellular Location: Cytoplasm. Cytoplasm > perinuclear region. Nucleus. Under normal redox growth conditions localizes in the cytoplasm and perinuclear NMRAL1蛋白抗体region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios. Similarity: Belongs to the NmrA-type oxidoreductase family. Database links: Entrez Gene: 57407 Human Entrez Gene: 67824 Mouse Entrez Gene: 287063 Rat SwissProt: Q9HBL8 Human SwissProt: Q8K2T1 Mouse SwissProt: P86172 Rat Unigene: 288969 Human Unigene: 372705 Mouse Unigene: 138656 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
NMRAL1蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid