尿激酶型纤溶酶原激活因子受体抗体
规格：1mg/1ml
英文名： uPA Receptor
别名： PLAUR; Plasminogen activator,urokinase receptor; Urokinase plasminogen activator surface receptor; Monocyte activation antigen Mo3; uPAR; U-PAR; MO3; UPAR; CD 87; CD87; CD87 antigen; MO 3; MO3; Monocy
分子量： 31kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PLAUR
交叉反应：Human, Mouse, Rat, Dog, Cow, Sheep,
尿激酶型纤溶酶原激活因子受体抗体细胞定位：细胞膜 分泌型蛋白
产品介绍：background: This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol(GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms.尿激酶型纤溶酶原激活因子受体抗体 The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq]. Function: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. Subcellular Location: Isoform 1: Cell membrane; Lipid-anchor, GPI-anchor. Isoform 2: Secreted (Probable).尿激酶型纤溶酶原激活因子受体抗体 Tissue Specificity: Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain. Similarity: Contains 3 UPAR/Ly6 domains. Gene ID: 5329 Database links: Entrez Gene: 5329 Human Entrez Gene: 18793 Mouse Entrez Gene: 50692 Rat Omim: 173391 Human SwissProt: Q03405 Human SwissProt: P35456 Mouse SwissProt: P49616 Rat Unigene: 466871 Human Unigene: 1359 Mouse Unigene: 82711 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
尿激酶型纤溶酶原激活因子受体抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 **学 信号转导 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid