NIPA1蛋白抗体
规格：1mg/1ml
英文名： NIPA1
别名： FSP 3; FSP3; Magnesium transporter NIPA1; MGC102724; MGC35570; NIPA 1; NIPA1; NIPA1_HUMAN; Non imprinted in Prader Willi/Angelman syndrome region protein 1; Non-imprinted in Prader-Willi/Angelman synd
分子量： 35kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NIPA1
交叉反应：Human, Mouse, Rat, Dog,
细胞定位：细胞膜
NIPA1蛋白抗体产品介绍：background: This gene encodes a magnesium transporter that associates with early endosomes and the cell surface in a variety of neuronal and epithelial cells. This protein may play a role in nervous system development and maintenance. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with autosomal dominant spastic paraplegia 6. [provided by RefSeq, Nov 2008] Function: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+). Subcellular Location: Cell membrane. Early endosome. Recruited to the cell membrane in response to low extracellular magnesium. Tissue Specificity: Widely expressed with highest levels in neuronal tissues.NIPA1蛋白抗体 DISEASE: Defects in NIPA1 are the cause of spastic paraplegia autosomal dominant type 6 (SPG6) [MIM:600363]. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Similarity: Belongs to the NIPA family. Gene ID: 123606 Database links: Entrez Gene: 123606 Human Entrez Gene: 233280 Mouse Entrez Gene: 308668 Rat Omim:NIPA1蛋白抗体 608145 Human SwissProt: Q7RTP0 Human SwissProt: Q8BHK1 Mouse Unigene: 511797 Human Unigene: 389901 Mouse Unigene: 443911 Mouse Unigene: 48451 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
NIPA1蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid