烟碱型乙酰胆碱受体β3抗体
规格：1mg/1ml
英文名： CHRNB3
别名： Nicotinic Acetylcholine Receptor beta 3 Beta-3 subunit precursor; CHRNB3; Neuronal acetylcholine receptor protein.
分子量： 51kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CHRNB3
交叉反应：Human, Mouse, Rat, Zebrafish, Chimpanzee,
细胞定位：细胞膜
烟碱型乙酰胆碱受体β3抗体产品介绍：background: The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 [PubMed 9009220]). Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N-terminal extracellular domain followed by 3 烟碱型乙酰胆碱受体β3抗体conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.[supplied by OMIM, Apr 2010] Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Subunit: Neuronal AChR seems to be composed of two different type of subunits: alpha and beta. Subcellular Location: Cell Membrane Database links: Entrez Gene: 464500 烟碱型乙酰胆碱受体β3抗体Chimpanzee Entrez Gene: 1142 Human Entrez Gene: 108043 Mouse Entrez Gene: 171131 Rat Entrez Gene: 380344 Xenopus laevis Entrez Gene: 317643 Zebrafish Omim: 118508 Human SwissProt: Q5IS75 Chimpanzee SwissProt: Q05901 Human SwissProt: Q8BMN3 Mouse SwissProt: P12391 Rat Unigene: 9694 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
烟碱型乙酰胆碱受体β3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid