核因子κB抑制蛋白样蛋白2抗体
规格：1mg/1ml
英文名： NFKBIL2
别名： I kappa B related protein; I-kappa-B-related protein; IkappaBR; IKBR; Inhibitor of kappa B related protein; Inhibitor of kappa B-related protein; MMS22L-interacting protein; MMS22L-interacting protein
分子量： 175kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NFKBIL2
交叉反应：Mouse, Rat, Dog, Horse,
细胞定位：细胞核 细胞浆
核因子κB抑制蛋白样蛋白2抗体产品介绍：background: The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008] Function: Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold. Subcellular 核因子κB抑制蛋白样蛋白2抗体Location: Cytoplasm. Nucleus. Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks. Tissue Specificity: Expressed in heart, skeletal muscle and tracheal epithelial cells. Similarity: Belongs to the Tonsoku family. Contains 3 ANK repeats. Contains 7 LRR (leucine-rich) repeats. Contains 8 TPR repeats. Gene ID: 4796 Database links: Entrez Gene: 505102 Cow Entrez Gene:核因子κB抑制蛋白样蛋白2抗体 475127 Dog Entrez Gene: 4796 Human Entrez Gene: 72749 Mouse Entrez Gene: 366953 Rat Omim: 604546 Human SwissProt: Q0P5G1 Cow SwissProt: Q96HA7 Human SwissProt: Q6NZL6 Mouse SwissProt: D4A615 Rat Unigene: 675285 Human Unigene: 358749 Mouse Unigene: 19092 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
核因子κB抑制蛋白样蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid