活化T细胞核因子胞浆相互作用蛋白2抗体
规格：1mg/1ml
英文名： NFATC2IP
别名： 45 kDa NF-AT-interacting protein; 45 kDa NFAT-interacting protein; cytoplasmic 2-interacting protein; ESC2; NF2IP_HUMAN; NFAT-interacting protein, 45-KD; NFATC2-interacting protein; Nfatc2ip; NIP45; N
分子量： 45kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NFATC2IP
交叉反应：Human, Mouse, Cynomolgus Monkey
细胞定位：细胞核
活化T细胞核因子胞浆相互作用蛋白2抗体产品介绍：background: NFATc2IP is a 419 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one ubiquitin-like domain. Interacting with NFATc2, TRAF1 and TRAF2, NFATc2IP plays a role in the inducible expression of cytokines in T-cells, specifically by enhancing NFATc2-induced interleukin (IL) production. NFATc2IP exists as three alternatively spliced isoforms and is subject to post-translational methylation; an event which augments NFATc2IP-regulated cytokine production. The gene encoding NFATc2IP maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, 活化T细胞核因子胞浆相互作用蛋白2抗体which is a gastrointestinal inflammatory condition. Function: Plays a role in the inducible expression of cytokine genes in T-cells, especially by increasing NFAT-driven IL-4 production. Subcellular Location: Nucleus. Cytoplasm. TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus. Post-translational modifications: Methylation at the N-terminus by PRMT1活化T细胞核因子胞浆相互作用蛋白2抗体 modulates interaction with the NFAT complex and results in augmented cytokine production. Similarity: Contains 1 ubiquitin-like domain. Database links: Entrez Gene: 84901 Human Entrez Gene: 18020 Mouse Entrez Gene: 308983 Rat Omim: 614525 Human SwissProt: Q9GLZ9 Cynomolgus Monkey SwissProt: Q8NCF5 Human SwissProt: O09130 Mouse SwissProt: Q6AYG7 Rat Unigene: 513470 Human Unigene: 1389 Mouse Unigene: 101030 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
活化T细胞核因子胞浆相互作用蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid