F-肌动蛋白结合蛋白抗体
规格：1mg/1ml
英文名： Nexilin
别名： 1110046H09Rik; AA553326; F-actin binding protein; F-actin-binding protein; MGC104234; MGC138865; MGC138866; Nelin; Nexilin; Nexn; NEXN_HUMAN; nF actin binding protein; OTTHUMP00000038336.
分子量： 81kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Nexilin
交叉反应：Human,
细胞定位：细胞浆
F-肌动蛋白结合蛋白抗体产品介绍：background: This gene encodes a filamentous actin-binding protein that may function in cell adhesion and migration. Mutations in this gene have been associated with dilated cardiomyopathy, also known as CMD1CC. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010] Function: Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. Subcellular Location: Cytoplasm; cytoskeleton. Cell junction; adherens junction. Cytoplasm; myofibril > sarcomere; Z line. Localizes to the cell-matrix AJ. Not found at the cell-cell AJ. Tissue Specificity: Abundantly expressed in heart and skeletal muscle, and at lower levels in placenta, lung, liver and pancreas. Also expressed in HeLa S3 and Molt-4 cells. DISEASE: Defects in NEXN are the cause of cardiomyopathy dilated type 1CC (CMD1CC) [MIM:613122]. A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in NEXN are the cause of cardiomyopathy familial hypertrophic type 20 (CMH20) [MIM:613876]. CMH20 is a hereditary heart disorder characterized by ventriculaF-肌动蛋白结合蛋白抗体r hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Similarity: Contains 1 Ig-like (immunoglobulin-like) F-肌动蛋白结合蛋白抗体domain. Gene ID: 91624 Database links: Entrez Gene: 91624 Human Entrez Gene: 68810 Mouse Entrez Gene: 246172 Rat Omim: 613121 Human SwissProt: Q0ZGT2 Human SwissProt: Q7TPW1 Mouse SwissProt: Q9Z2J4 Rat Unigene: 612385 Human Unigene: 200188 Mouse Unigene: 107975 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
F-肌动蛋白结合蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 信号转导 结合蛋白 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid