NEURL4蛋白抗体
规格：1mg/1ml
英文名： NEURL4
别名： KIAA1787; NEUL4_HUMAN; Neuralized-like protein 4; neurl4.
分子量： 167kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NEURL4
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
NEURL4蛋白抗体产品介绍：background: NEURL4 (neuralized homolog 4 (Drosophila)), also known as neuralized-like protein 4, is a 1,562 amino acid protein that is highly expressed in a wide variety of tissues. Containing six NHR (neuralized homology repeat) domains, NEURL4 exists as two alternatively spliced isoforms that are encoded by a gene that maps to human chromosome 17p13.1. Chromosome 17 comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, and is linked to predisposition of cancers of the ovary, colon, prostate gland and fallopian tubes. Function: Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and NEURL4蛋白抗体preventing formation of ectopic microtubular organizing centers. Subunit: Interacts with CCP110; this interaction propmotes CCP110 ubiquitination and degradation via the proteasome pathway. Via its interaction with CCP110, may indirectly interact with CEP97. Interacts with the E3 ubiquitin-protein ligase HERC2 and UBE3A. May interact with MAPK6 and hence mediate MAPK6 interaction with UBE3A. Interaction with UBE3A NEURL4蛋白抗体may be indirect and mediated by HERC2. Subcellular Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Tissue Specificity: Widely expressed at high levels (including brain). Post-translational modifications: Ubiquitinated; undergoes HERC2-dependent 'Lys-48' ubiquitination. This ubiquitination leads to proteasomal degradation. Similarity: Contains 6 NHR (neuralized homology repeat) domains. Gene ID: 84461 Database links: Entrez Gene: 84461 Human SwissProt: Q96JN8 Human Unigene: 654794 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
NEURL4蛋白抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid