DNA拓普西异构酶ⅡA抗体
规格：1mg/1ml
英文名： TOP2A
别名： Topoisomerase Ⅱalpha; DNA topoisomerase II, alpha isozyme; DNA topoisomerase 2 alpha; DNA topoisomerase II 170 kD; DNA Topoisomerase2; TOP2; TOP2A; TopII alpha; Topo II alpha; Topoisomerase DNA II alp
分子量： 174kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TOP2 alp
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞核 细胞浆
DNA拓普西异构酶ⅡA抗体产品介绍：background: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]. Function: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase IIDNA拓普西异构酶ⅡA抗体 makes double-strand breaks. Subunit: Homodimer. Interacts with COPS5. Subcellular Location: Cytoplasm. Nucleus, nucleoplasm. Note=Generally located in the nucleoplasm. Post-translational modifications: Phosphorylation has no effect on catalytic activity.DNA拓普西异构酶ⅡA抗体 However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation. Similarity: Belongs to the type II topoisomerase family. Gene ID: 7153 Database links: Entrez Gene: 7153 Human Entrez Gene: 21973 Mouse Entrez Gene: 360243 Rat Omim: 126430 Human SwissProt: P11388 Human SwissProt: Q01320 Mouse SwissProt: P41516 Rat Unigene: 156346 Human Unigene: 4237 Mouse Unigene: 90996 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
DNA拓普西异构酶ⅡA抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 染色质和核信号 信号转导 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid