肾连蛋白抗体
规格：1mg/1ml
英文名： Nephronectin
别名： EGFL6L; Nephronectin; NPNT; NPNT_HUMAN; POEM; Preosteoblast EGF like repeat protein with MAM domain; Preosteoblast EGF-like repeat protein with MAM domain; Protein EGFL6 like; Protein EGFL6-like.
分子量： 59kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Nephrone
交叉反应：Human, Mouse, Rat, Rabbit,
细胞定位：分泌型蛋白
肾连蛋白抗体产品介绍：background: Nephronectin is a 565 amino acid member of the nephronectin family that contains five EGF-like domains and an Arg-Gly-Asp (RGD) cell binding motif, as well as a meprin, A5 protein and receptor protein-tyrosine phosphatase µ (MAM) domain. Expressed in kidney, thyroid and parathyroid glands, developing bone, tooth germ, skeletal and smooth muscle, brain and skin, POEM is involved in the development and function of bone, muscle and kidney tissue. The most established function of POEM is as a ligand to the receptor Integrin å8/∫1. Highly expressed in the nephritic cord, Integrin å8/∫1 plays a critical role in kidney morphogenesis and development. The POEM-Integrin å8∫1 complex regulates the expression of GDNF, another protein that affects kidney development, specifically by regulating the growth of the uretic bud. There are two named isoforms of POEM, both of which form homodimers or homotrimers. Function: Functional ligand of integrin alpha-8/beta-1 肾连蛋白抗体in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins. Subcellular Location: Secreted > extracellular space > extracellular matrix. Trapped on the cell surface or in the extracellular matrix. Tissue Specificity: Expressed in kidney and lung and to a lower extent in brain, pregnant uterus, placenta, thyroid gland and blood vessels. Similarity: Belongs to肾连蛋白抗体 the nephronectin family. Contains 5 EGF-like domains. Contains 1 MAM domain. Gene ID: 255743 Database links: Entrez Gene: 255743 Human Entrez Gene: 114249 Mouse Omim: 610306 Human SwissProt: Q6UXI9 Human SwissProt: Q91V88 Mouse Unigene: 518921 Human Unigene: 279310 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肾连蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid