Toll样受体1抗体
规格：1mg/1ml
英文名： TLR1
别名： Toll-like receptor 1; GD2:CD281; CD281 antigen; rsc786; Similar to Drosophila Toll protein; TIL; Toll (Drosophila) homolog; Toll like receptor 1 Precursor; Toll/Interleukin 1 receptor like; TLR1_HUMAN
分子量： 87(hu,mo)/91(ratkDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TLR1
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse,
细胞定位：
Toll样受体1抗体产品介绍：background: TLR1 is a member of the Toll like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. The gene encoding TLR1 is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. Function: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).Toll样受体1抗体 Subunit: Binds MYD88 (via TIR domain). Interacts with CNPY3 (By similarity). Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2. Subcellular Location: Cell membrane; Single-pass type I membrane protein (By similarity). Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein (By similarity). Tissue Specificity: Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine. Similarity: Belongs to the Toll-like receptor family. Contains 19 LRR (leucine-rich) repeats.Toll样受体1抗体 Contains 1 LRRCT domain. Contains 1 TIR domain. Gene ID: 7096 Database links: Entrez Gene: 7096 Human Entrez Gene: 21897 Mouse Omim: 601194 Human SwissProt: Q15399 Human SwissProt: Q9EPQ1 Mouse Unigene: 621817 Human Unigene: 654532 Human Unigene: 273024 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Toll样受体1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid