E3泛素蛋白连接酶HECW2抗体
规格：1mg/1ml
英文名： NEDL2
别名： C2 and WW domain-containing protein 2; E3 ubiquitin protein ligase HECW2; E3 ubiquitin-protein ligase HECW2; HECT; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2; Hecw2; HECW2_HUMAN;
分子量： 176kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NEDL2
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆
E3泛素蛋白连接酶HECW2抗体产品介绍：background: NEDL2 is a 1,572 amino acid cytoplasmic protein that is involved in protein modification and ubiquitination and exists as two alternatively spliced isoforms. NEDL2 acts as an E3 ubiquitin-protein ligase that enhances p73 transcription activation, ubiquitination and stabilization, and is highly expressed in ***** heart, lung and brain. Containing one C2 domain, two WW domains and a single HECT (E6AP-type E3 ubiquitin-protein ligase) domain, NEDL2 is encoded by a gene that maps to human chromosome 2, which consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstr鰉 syndrome. Function: E3 ubiquitin-protein ligaseE3泛素蛋白连接酶HECW2抗体 that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. Subcellular Location: Cytoplasm. Tissue Specificity: Predominantly expressed in ***** brain, lung and heart. Similarity: Contains 1 C2 domain. Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. Contains 2 WW domains. Gene ID: 57520 Database links: Entrez Gene: 57520 Human Entrez E3泛素蛋白连接酶HECW2抗体Gene: 329152 Mouse Entrez Gene: 100155879 Pig Entrez Gene: 316395 Rat SwissProt: Q9P2P5 Human SwissProt: Q6I6G8 Mouse Unigene: 654742 Human Unigene: 132150 Mouse Unigene: 447527 Mouse Unigene: 198842 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
E3泛素蛋白连接酶HECW2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 表观遗传学 泛素
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid