开角型青光眼Myocilin抗体
规格：1mg/1ml
英文名： Myocilin
别名： Glaucoma 1 open angle; Glaucoma 1 open angle; GLC1A; GPOA; JOAG; JOAG1; Mutated trabecular meshwork-induced glucocorticoid response protein; MYOC; MYOC_HUMAN; Myocilin; Myocilin, trabecular meshwork i
分子量： 53kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Myocilin
交叉反应：Human, Mouse, Rat, Rabbit,
细胞定位：分泌型蛋白
开角型青光眼Myocilin抗体产品介绍：background: MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma. [provided by RefSeq, Jul 2008] Function: May participate in the obstruction of fluid outflow in the trabecular meshwork. Subcellular Location: Rough endoplasmic reticulum. Secreted. Cell projection > cilium. Located preferentially in the ciliary rootlet and basal body of the connecting cilium of photoreceptor cells, and in the rough endoplasmic reticulum. Also secreted. Tissue Specificity: Expressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart and other tissues. Expressed predominantly in the retina. In normal eyes, found in the inner uveal meshwork region and the anterior portion of the meshwork. In contrast, in many glaucomatous eyes, it is found in more regions of the meshwork and appeared more intensively than in normal 开角型青光眼Myocilin抗体eyes, regardless of the type or clinical severity of glaucoma. Post-translational modifications: Different isoforms may arise by post-translational modifications. Glycosylated. Palmitoylated. DISEASE: Defects in MYOC are the cause of primary open angle glaucoma type 1A (GLC1A) [MIM:137750]. Primary open angle glaucoma (POAG) is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. Defects in MYOC may also contribute to primary congenital glaucoma 开角型青光眼Myocilin抗体type 3A (GLC3A) [MIM:231300]. Defects in MYOC may contribute to this phenotype via digenic inheritance. GLC3A is an autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early choldhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor. Similarity: Contains 1 olfactomedin-like domain. Gene ID: 4653 Database links: Entrez Gene: 4653 Human Entrez Gene: 17926 Mouse Entrez Gene: 81523 Rat Omim: 601652 Human SwissProt: Q99972 Human SwissProt: O70624 Mouse SwissProt: Q9R1J4 Rat Unigene: 436037 Human Unigene: 10694 Mouse Unigene: 30051 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
开角型青光眼Myocilin抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid