肌球蛋白9B抗体
规格：1mg/1ml
英文名： MYO9B
别名： CELIAC 4; Celiac disease 4; CELIAC4; MYO 9B; Myosin 9B; Myosin IX; Myosin IXB; Myosin9B; MyosinIX; MyosinIXB; MYR 5; MYR5; Unconventional myosin 9b.
分子量： 243kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MYO9B
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆
肌球蛋白9B抗体产品介绍：background: This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. May be involved in the remodeling of the actin cytoskeleton. Binds actin with high affinity both in肌球蛋白9B抗体 the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activating protein on Rho. Subcellular Location: Cytoplasm; cell cortex. Cytoplasm; perinuclear region. Note=In undifferentiated cells colocalizes with F-actin in the cell periphery while in differentiated cells its localization is cytoplasmic with the highest levels in the perinuclear region. Database links: Entrez 肌球蛋白9B抗体Gene: 4650 Human Entrez Gene: 17925 Mouse Omim: 602129 Human SwissProt: Q13459 Human SwissProt: Q9QY06 Mouse SwissProt: Q63358 Rat Unigene: 159629 Human Unigene: 33779 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品应用：肌球蛋白9B抗体WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid