髓鞘表达因子2抗体
规格：1mg/1ml
英文名： Myelin expression factor 2
别名： MYEF2; KIAA1341; MEF 2; MST156; MYEF2_HUMAN; MYEF 2; Myelin expression factor 2.
分子量： 64kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Myelin e
交叉反应：Human,
细胞定位：细胞核
髓鞘表达因子2抗体产品介绍：background: Myelin basic protein (MBP) binds to negatively charged lipids on the cytosolic surface of oligodendrocyte membranes and is responsible for adhesion of these surfaces in multilayered Myelin sheaths. As a member of a larger family of proteins with many forms and post-translational modifications, MBP appears to have several other functions as a result of these modifications, including participating in the transmission of extracellular signals, as well as cell signaling. These modifications of MBP are dynamic during normal central nervous system (CNS) development and during Myelin degeneration in multiple sclerosis (MS). Regulation of the human MBP gene occurs at the MB1 regulatory motif located between nucleotides -14 to -50. The MB1 element contains binding sites for both the activator 髓鞘表达因子2抗体protein MEF-1/Pur?and the repressor protein MYEF2. MYEF2 is a nuclear protein whose expression is developmentally regulated in mouse brain with peak expression occurring at postnatal day 7. Four isoforms of MYEF2 exist due to alternative splicing events. Function: Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to髓鞘表达因子2抗体 MB1 and function are inhibited by PURA. Subunit: Monomer (By similarity). Subcellular Location: Nuclear Similarity: Contains 3 RRM (RNA recognition motif) domains. Gene ID: 50804 Database links: Entrez Gene: 50804 Human Entrez Gene: 17876 Mouse SwissProt: Q9P2K5 Human SwissProt: Q8C854 Mouse Unigene: 6638 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
髓鞘表达因子2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 转录调节因子 表观遗传学
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid