MUTED蛋白抗体
规格：1mg/1ml
英文名： MUTED
别名： Biogenesis of lysosomal organelles complex 1, subunit 5, muted; Biogenesis of lysosome related organelles complex 1 subunit 5; BLOC 1 subunit 5; BLOS5; MU; MUTED; Muted homolog; Muted protein homolog;
分子量： 21kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MUTED
交叉反应：Human, Dog, Cow, Horse,
MUTED蛋白抗体细胞定位：细胞浆 细胞膜
产品介绍：background: This gene encodes a mitochondrial protein that is a member of the solute carrier family. Although this protein was initially thought to be the mitochondrial deoxynucleotide carrier involved in the uptake of deoxynucleotides into the matrix of the mitochondria, further studies have demonstrated that this protein instead functions as the mitochondrial thiamine pyrophosphate carrier, which transports thiamine pyrophosphates into mitochondria. Mutations in this gene cause microcephaly, Amish type, a metabolic disease that results in severe congenital microcephaly, severe 2-ketoglutaric aciduria, and death within the first year. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008] Function: The BLOC-1 complex is required for normal biogenesis MUTED蛋白抗体of lysosome-related organelles, such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Subunit: Interacts with BLOC1S4, DTNBP1/BLOC1S7 and PI4K2A (By similarity). Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOC-1 complex MUTED蛋白抗体associates with the AP-3 protein complex and membrane protein cargos. Interacts with BLOC1S6. Similarity: Belongs to the Muted family. Gene ID: 63915 Database links: Entrez Gene: 63915 Human Entrez Gene: 17828 Mouse Omim: 607289 Human SwissProt: Q8TDH9 Human SwissProt: Q8R015 Mouse Unigene: 719272 Human Unigene: 261554 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MUTED蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid