磷酸化神经突触前膜胞内蛋白18抗体
规格：1mg/1ml
英文名： phospho-Munc18-1 (Thr574)
别名： Munc18-1 (phospho T574); p-Munc18-1 (phospho T574); FLJ37475; Munc 18 1; Munc 18a; MUNC18 1; N-Sec1; Neuronal SEC1; NSec1; p67; Protein unc-18 homolog 1; Protein unc-18 homolog A; Rb sec1; RBSEC1; STX
分子量： 68kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆 细胞膜
磷酸化神经突触前膜胞内蛋白18抗体产品介绍：background: This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010] Function: May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. Subcellular Location: 磷酸化神经突触前膜胞内蛋白18抗体Cytoplasm. Membrane. Tissue Specificity: Brain and spinal cord. Highly enriched in axons. DISEASE: Defects in STXBP1 are the cause of epileptic encephalopathy early infantile type 4 (EIEE4) [MIM:612164]. Affected individuals have neonatal or infantile onset of seizures, suppression-burst pattern on EEG, profound mental retardation, and MRI evidence of hypomyelination. Similarity: Belongs to磷酸化神经突触前膜胞内蛋白18抗体 the STXBP/unc-18/SEC1 family. Database links: Entrez Gene: 6812 Human Entrez Gene: 20910 Mouse Entrez Gene: 25558 Rat Omim: 602926 Human SwissProt: P61764 Human SwissProt: O08599 Mouse SwissProt: P61765 Rat Unigene: 288229 Human Unigene: 278865 Mouse Unigene: 80843 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化神经突触前膜胞内蛋白18抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid