核受体共激活因子5抗体
规格：1mg/1ml
英文名： NCOA5
别名： bA465L10.6; CIA; Coactivator independent of AF 2; KIAA1637; MGC28864; NCoA 5; NCOA5; Nuclear receptor coactivator 5; OTTMUSP00000001057; RP23-61O3.13.
分子量： 66kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NCOA5
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Ferret, Rhesus monkey, Gorilla, Orangutan, Elephant
细胞定位：细胞核
核受体共激活因子5抗体产品介绍：background: This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined. [provided by RefSeq, Jul 2008] Function: Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, 核受体共激活因子5抗体and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) 核受体共激活因子5抗体as well as the corepression of MYC in response to 17-beta-estradiol (E2). Subunit: Binds HTATIP2/TIP30. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and PPP1CA. Subcellular Location: Nucleus. Tissue Specificity: Widely expressed. Database links: Entrez Gene: 57727 Human SwissProt: Q9HCD5 Human Unigene: 654991 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
核受体共激活因子5抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid