视网膜钠/钾/钙交换体2抗体
规格：1mg/1ml
英文名： NCKX2
别名： Na(+)/K(+)/Ca(2+) exchange protein 2; Na(+)/K(+)/Ca(2+)-exchange protein 2; NCKX 2; NCKX2_HUMAN; OTTHUMP00000045115; Retinal cone Na Ca+K exchanger; Retinal cone Na-Ca+K exchanger; SLC24A2; Sodium/pot
分子量： 74kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NCKX2
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
视网膜钠/钾/钙交换体2抗体产品介绍：background: This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] Function: Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone视网膜钠/钾/钙交换体2抗体photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Subcellular Location: Membrane. Similarity: Belongs to视网膜钠/钾/钙交换体2抗体 the sodium/potassium/calcium exchanger family. SLC24A subfamily. Database links: Entrez Gene: 25769 Human Entrez Gene: 76376 Mouse Entrez Gene: 84550 Rat Omim: 609838 Human SwissProt: Q9UI40 Human SwissProt: O54701 Rat Unigene: 283014 Human Unigene: 208755 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
视网膜钠/钾/钙交换体2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid