DR1相关蛋白1抗体
规格：1mg/1ml
英文名： NC2 alpha
别名： DR1 associated corepressor; DR1 associated protein 1 (negative cofactor 2 alpha); DR1 associated protein 1; DR1 associated protein1; Dr1-associated corepressor; Dr1-associated protein 1; DRAP 1; DRAP1
分子量： 22kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NC2 alph
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
产DR1相关蛋白1抗体品介绍：background: Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008] Function: The association of the DR1/DRAP1 heterodimer with TBP results in a DR1相关蛋白1抗体functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Ref. Subunit: Heterodimer with DR1. Binds BTAF1. Subcellular Location: Nucleus Tissue Specificity: Ubiquitous. Highly expressed in ***** testis, heart, skeletal muscle, pancreas and brain, and in fetal brain, liver and kidney. Post-translational modifications: Phosphorylation reduces DNA binding, but has no effect on heterodimerization and TBP binding. Similarity: Belongs to the NC2 alpha/DRAP1 family. Contains 1 histone-fold domain. Gene ID: 10589 Database links: Entrez Gene:DR1相关蛋白1抗体 10589 Human Entrez Gene: 540345 Cow Entrez Gene: 66556 Mouse Entrez Gene: 293674 Rat Omim: 602289 Human SwissProt: Q2YDP3 Cow SwissProt: Q14919 Human SwissProt: Q9D6N5 Mouse SwissProt: A0JPP1 Rat Unigene: 356742 Human Unigene: 275446 Mouse Unigene: 40582 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
DR1相关蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 结合蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid