核自身抗原精子蛋白NASP抗体
规格：1mg/1ml
英文名： NASP
别名： 5033430J04Rik; AI131596; AI317140; D4Ertd767e; DKFZp547F162; Epcs32; FLB7527; FLJ31599; FLJ35510; MGC19722; MGC20372; MGC2297; MGC93869; NASP; NASP_HUMAN; nuclear autoantigenic sperm protein (histone
分子量： 85kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NASP
交叉反应：Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
核自身抗原精子蛋白NASP抗体产品介绍：background: This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008] Function: Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. Subcellular Location核自身抗原精子蛋白NASP抗体: Cytoplasm. Nucleus. Tissue Specificity: Isoform 1 is testis- and sperm-specific. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the NASP family. Contains 3 TPR repeats. Gene ID: 4核自身抗原精子蛋白NASP抗体678 Database links: Entrez Gene: 4678 Human Entrez Gene: 512427 Cow Entrez Gene: 50927 Mouse Entrez Gene: 100009592 Rabbit Entrez Gene: 298441 Rat Omim: 603185 Human SwissProt: Q2T9P4 Cow SwissProt: P49321 Human SwissProt: Q99MD9 Mouse SwissProt: P27123 Rabbit SwissProt: Q66HD3 Rat Unigene: 319334 Human Unigene: 257181 Mouse Unigene: 48344 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
核自身抗原精子蛋白NASP抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 染色质和核信号 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid